Researchers offer new insights into animal-to-human disease transmission

Researchers offer new insights into animal-to-human disease transmission

Researchers offer new insights into animal-to-human disease transmission

Key findings on who gets sick and why from the Dynamic Drivers of Disease in Africa Consortium are being shared at One Health for the Real World: zoonoses, ecosystems and wellbeing, a high-level international symposium taking place at the Zoological Society of London this week.

Jeremy Farrar, Director, Wellcome Trust

Jeremy Farrar, Director, Wellcome Trust

Resilient global health systems, strong civil society and leadership for those health systems and broad research agendas from disparate fields are the three essentials to face the challenges of 21st century equity and health, according to Professor Jeremy Farrar, Director of the Wellcome Trust.

Speaking at  the One Health for the Real World: zoonoses, ecosystems and wellbeing symposium, co-organised by the STEPS-led Dynamic Drivers of Disease in Africa Consortium and the Zoological Society of London, with support from the Royal Society, Professor Farrar stressed that people were not passive observers in history and could bring about these changes.

However he said a move to individualised medicine would act against public access, equity and a holisitic approach to health.

Key findings from the Drivers of Disease consortium are being shared with high-level policymakers, practitioners and academics at the two-day symposium, which is taking place at the Zoological Society of London. They include representatives of the World Health Organization, the UK Department for International Development, the UN Food and Agricultural Organization and EcoHealth Alliance.

The Consortium has been researching the relationships between diseases transmitted from animals to people (zoonoses), ecosystems and wellbeing for the past four years. In particular it has explored henipavirus infection in Ghana, Rift Valley fever in Kenya, Lassa fever in Sierra Leone, and trypanosomiasis (sleeping sickness) in Zambia and Zimbabwe.

One Health

Importantly, it took a One Health approach to its research. One Health recognises the interconnectedness of human and animal health with environmental health. It seeks to promote the collaborative effort of multiple disciplines, working locally, nationally and globally to attain optimal health for people, animals and the environment.

The Drivers of Disease Consortium involved 20 partners in Africa, Europe and America. It saw social scientists from STEPS (IDS/University of Sussex) working together with ecologists, epidemiologists, virologists and other natural scientists – with the integration of multiple disciplines and research approaches proving essential to learn how diseases transmit from animals to people.

Local and participatory

The research has underlined the value of taking a ‘local’ approach. First, understanding the local circumstances in which diseases pass from animals to people was shown to be essential for disease preparedness and prevention.

Second, participatory research undertaken by the Consortium showed the importance of considering local people’s various perspectives to open up new lines of inquiry and reveal links otherwise missed.

Policy and practice

Professor Melissa Leach, Director of the Institute of Development Studies (IDS) and lead researcher for the Consortium, said: “This work has many implications for policy and practice. It suggests opportunities for new integrated interventions involving collaboration between vets, medics, environmental planners, agricultural technicians, social development practitioners and more.

“Such interventions need to be adapted to diverse local settings and contexts yet also have the potential to scale up and out. Identifying and taking these opportunities forward is what doing ‘One Health for the real world’ means.”

Silos and hierarchies

She added that the work was just beginning: “Unfortunately, there are forces that make the One Health approach difficult. These include the tendency for sectoral and disciplinary silos and the dominance of old hierarchies, interests and perspectives. Findings ways to overcome these forces is the key challenge now.”

The research has been funded by the Ecosystem Services for Poverty Alleviation (ESPA) programme. ESPA spokesperson Rob Bruce said: “We are a proud partner in this project. The work of the team has been phenomenal, delivering real game-changing science that could genuinely save and improve lives. This is what ESPA is all about: helping nature to help people in an effort to make the world a better place for both.”

This originally appeared on the Institute for Development Studies website on 17th March, 2016 authored by Naomi Marks. Available at: http://www.ids.ac.uk/news/researchers-offer-new-insights-into-animal-to-human-disease-transmission

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New SARS-like virus is poised to infect humans

New SARS-like virus is poised to infect humans

New SARS-like virus is poised to infect humans

Otonycteris_hemprichiiA SARS-like virus found in Chinese horseshoe bats may be poised to infect humans without the need for adaptation, overcoming an initial barrier that could potentially set the stage for an outbreak according to a study at the University of North Carolina at Chapel Hill.

The work, led by Ralph Baric, Ph.D., professor of epidemiology at UNC’s Gillings School of Global Public Health, comes on the heels of two recent high-profile outbreaks – Ebola and Zika – for which there are no vaccines. The two outbreaks combined claimed thousands of lives and cost billions in foregone economic growth.

“The capacity of this group of viruses to jump into humans is greater than we originally thought,” said Vineet Menachery, Ph.D., the study’s first author. “While other adaptations may be required to produce an epidemic, several viral strains circulating in bat populations have already overcome the barrier of replication in human cells and suggest reemergence as a distinct possibility.”

Baric and Menachery worked with SARS-like coronavirus sequences isolated from Chinese horseshoe bats, where SARS originated. Based on the sequences, they reconstructed the viruses to evaluate their potential to infect human cells and in mice. They found that the newly identified virus, known as WIV1-CoV, could bind to the same receptors as SARS-CoV. They also showed that the virus readily and efficiently replicated in cultured human airway tissues, suggesting an ability to jump directly to humans.

“To be clear, this virus may never jump to humans, but if it does, WIV1-CoV has the potential to seed a new outbreak with significant consequences for both public health and the global economy,” said Vineet, whose work is reported in the Mar. 13, 2016 online version of theProceedings of the National Academy of Sciences.

The research team also found that antibodies developed to treat SARS were effective in both human and animal tissue samples against WIV1-CoV, providing a potent treatment option if there were an outbreak. However, the limitation to treat with antibodies is the same as with ZMapp, the antibody approach used for Ebola: producing it at a large enough scale to treat many people. Also, in terms of prevention, existing vaccines against SARS would not provide protection for this new virus due to slight differences in the viral sequence.

SARS, short for severe acute respiratory syndrome, was first seen in an outbreak in 2002 and resulted in 8,000 cases and nearly 800 deaths. Spread through airborne contact, its onset presents symptoms similar to the flu with a dry cough but can accelerate rapidly to pneumonia, filling the lungs with fluid and putting extreme stress on the body’s immune system. According to the Centers for Disease Control and Prevention, SARS’ mortality rate can range from less than one percent in patients below 24 years old to more than 50 percent in patients aged 60 and older. Baric and his team believe that WIV1-CoV has the potential to induce similar results with proper adaptation to humans.

“This type of work generates information about novel viruses circulating in animal populations and develops resources to help define the threat these pathogens may pose to human populations,” Baric said. “It’s important to note that it’s not an approach that’s limited to SARS or SARS-like viruses. It can be applied to other emerging pathogens to helping us prepare for the next emergent virus, whether it be MERS, the Zika virus or something we haven’t even heard of yet.”

This post originally appeared on the ScienceBlog website on 14th March, 2016. Available at: http://scienceblog.com/483306/new-sars-like-virus-poised-infect-humans/


 

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Kenya Zoonotic Diseases Priority Map

Kenya Zoonotic Diseases Priority Map

Kenya Zoonotic Diseases Priority Map

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‘Here And Now’: Tracing The Wisconsin Elizabethkingia Outbreak

‘Here And Now’: Tracing The Wisconsin Elizabethkingia Outbreak

‘Here And Now’: Tracing The Wisconsin Elizabethkingia Outbreak

Federal, State Officials Work To Pinpoint Source Of Rare Disease

As tracked by the Wisconsin Department of Health Services, cases of Elizabethkingia have been reported in Columbia, Dane, Dodge, Fond du Lac, Jefferson, Milwaukee, Ozaukee, Racine, Sauk, Sheboygan, Washington and Waukesha counties. Most of the victims have been older than 65, and all were dealing with a serious illness of some kind at the time.

In a March 11, 2016 interview on Wisconsin Public Television’s “Here And Now,” Michael Bell, deputy director for the Division of Healthcare Quality Promotion at the Centers for Disease Control and Prevention in Atlanta, shared what federal health officials know about the outbreak so far. He also explained why epidemiologists are having trouble determining its source.

Over a typical year, health officials generally report a half dozen or more Elizabethkingia infections in each state, Bell told host Frederica Freyberg, so it’s unusual to see so many cases concentrated in one geographic area within a few months.

“We don’t see 48 of the identical organism causing an outbreak like this very often,” he said. “In fact, this is probably the largest one we’ve seen.”

Bell explained that it can take about two weeks in the lab to determine whether or not a sample is contaminated with a specific bacteria. CDC and state officials have examined potential sources — including drinking water, medical products, healthcare facilities, and patients’ homes — but have yet to find a smoking gun. The best lead so far is that all of the Elizabethkingia anophelis specimens identified so far turned out to have the same genetic “fingerprint,” or marker of variation within its species — akin to genetic similarities among people born from the same mother.

“The fact that they all have one fingerprint makes us think that it could be one isolated source,” Bell said.

Bell also pointed out the upsides: Elizabethkingia is not contagious, people with healthy immune systems can easily avoid infection, and medical providers have identified some antibiotics that work against the strain found in Wisconsin.

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It is time to rethink the way we handle pets and wildlife

It is time to rethink the way we handle pets and wildlife

It is time to rethink the way we handle pets and wildlife

In Summary

  • During the Kenya Medical Research Institute’s fifth scientific conference, which also took place in February, scientists raised the alarm over the transmission of diseases from animal to humans.
  • The World Health Organisation says that 60 per cent of the pathogens that cause infectious diseases in human beings come from animals.
  • According to the US’s Centre for Disease Control and prevention, zoonoses include a wide range of diseases, ranging from mass killers such as anthrax, Ebola, swine flu, West Nile Virus, bird flu, Crimean-Congo haemorrhagic fever and the Hendra Virus to subtle and slow killers like rabies, Rift Valley Fever and Brucellosis

During the funeral of a 39-year old woman who died of Aids in Homa Bay in February this year, a clinical officer who had attended to her engaged DN2 in a discussion about the Zika Virus in South America, and how it had triggered yet another debate on how man’s unguided relationship with nature is hurting him.

Sadly, neither the potential victims, nor the government, are adequately conversant of this to take the necessary precautions.

It is worth noting that at the time the Homa Bay funeral was taking place, across the Atlantic Ocean in Boston, US, the annual Conference on Retroviruses and Opportunistic Infections (CROI) was also taking place. The discussion focused on yet another deadly infection that came to human beings from animals: Ebola.

In Kenya, the Ministry of Health allayed fears of possible disease outbreaks from the Ebola and Zika viruses.

Only a few scientists, like Lancet Laboratory’s executive officer, Dr Ahmed Kalebi, took note of the public health issues raised at CROI.

Meanwhile, during the Kenya Medical Research Institute’s (KEMRI) fifth scientific conference, which also took place in February, scientists raised the alarm over the transmission of diseases from animal to humans. They expressed concern about humans’ continued intrusion into wildlife territory.

Whether it is the burgeoning population or the desire to live in quiet, exclusive environments, human intrusion into animal habitats has grown considerably in the country in recent times.

The area around the Lewa Conservancy which straddles Meru and Laikipia counties, is a case in point. Apart from the herds of elephants and buffalos that roam the plains, one can also spot residential houses tucked away in between the trees.

A great deal has been documented about the booming real estate business in Laikipia County, which for decades was dominated by large territorial mammals such as rhinos, elephants and buffaloes.

Not surprisingly, this intrusion has seen elephants destroy crops in the areas neighbouring their habitat.

Now, experts are warning of a threat greater than the destruction of crops of trampling to death of humans: zoonoses.
Zoonoses are diseases transmitted from animals to humans.

The World Health Organisation, (WHO) says that 60 per cent of the pathogens that cause infectious diseases in human beings come from animals.

And researchers warn that the close interaction between humans and animals, whether wild or domesticated, is increasingly making Kenyans ill.

According to the US’s Centre for Disease Control and prevention, zoonoses include a wide range of diseases, ranging from mass killers such as anthrax, Ebola, swine flu, West Nile Virus, bird flu, Crimean-Congo haemorrhagic fever and the Hendra Virus to subtle and slow killers like rabies, Rift Valley Fever and Brucellosis.

Although these diseases are a global health problem, their impact is felt more in Africa than in other parts of the world because they tend to be neglected. African governments dedicate few or no resources to detect and respond to them at the local or national levels. Only 0.7 per cent of these diseases affect people in developed countries as poor nations bear the brunt.

It was only after the Ebola outbreak in West Africa in 2013, which wreaked havoc in West Africa, that people started paying attention to the usually muted voice of researchers on the link between diseases, animals and the environment.

PUTTING UP SKYCRAPPERS

Given the rate at which construction is going on in the country, it is time we sat up and took notice.

Not too long ago, the ambience in Nairobi’s upmarket Kilimani allowed residents and colobus monkeys to live in harmony. Today, the gibbering of monkeys has been replaced by the roar of construction machines putting up skyscrapers.

The same trend can be observed in other parts of the country such as Lower and Upper Kabete, Gathiga, slightly past Kitisuru in Nairobi, Mang’u (Kiambu County), Kabarak and Sobea (Nakuru County) Nyahera (Kisumu County and Kapchorua in Nandi Hills (Nandi County).

Unknown to many, as this trend continues, disease-causing pathogens are mutating, becoming more lethal and embedding themselves in the complex yet delicate human food chain and way of life.

A study in 2012 titled “Zoonoses: A potential Obstacle to the Growing Wildlife Industry of Namibia published in the journal, Infection Ecology and Epidemiology, drew a chilling pattern in Kenya, similar to Namibia’s cases of zoonoses: the serum of buffaloes in Ijara, Nakuru, Laikipia, Nairobi and parts of the North Rift tested positive for antibodies of Rift Valley Fever.

Dr Eric Osoro, a medical epidemiologist at the Zoonotic Diseases Unit (ZDU) in the Ministry of Health, says that at least 2,000 Kenyans die of rabies every year, which is unfortunate, given that it costs less than Sh100 to vaccinate a dog, compared with the thousands of shillings required to treat the viral disease.

“The number of rabies deaths reported is a gross underestimation of the actual number of deaths that occur in Kenya annually from this terrifying fatal disease,” he says.

Many more Kenyans could be dying of rabies, which can be caused even by a scratch by an unvaccinated dog, because the incubation period for the virus is estimated to be about two months.

“Sometimes the wound might have even healed, so none one would suspect it is rabies,” Dr Osoro says.

While rabies can be prevented by vaccinating dogs, WHO says it is 100 per cent fatal once the clinical signs appear.

Apart from rabies, Dr Osoro also cautioned about Brucellosis — a disease one gets from taking milk that has not been boiled properly — and anthrax.

“Anthrax kills cattle in less than 12 hours, but many will consume the flesh because the animal looked healthy,” he says.

Prof Thumbi Mwangi, a clinical assistant professor at Washington State University in the US and a researcher on zoonoses at the Kenya Medical Research Institute (KEMRI), told DN2 that while the interaction between humans and animals is not necessarily a bad thing, failure to keep healthy animals increases the chances of ill health for humans.

PATHOGENS FIND NEW HOSTS

In March last year, Prof Mwangi carried out a study in which he tracked 1,500 households and their livestock in 10 villages in Western Kenya. He and his team obtained data on 6,400 adults and children, 8,000 cattle, 2,400 goats, 1,300 sheep and 18,000 chicken.

The results, published in the open journal, Plos One, revealed that for every 10 cases of animal illnesses or deaths that occurred, the probability of human sickness in the same household increased by about 31 per cent.

Prof Eric Fèvre, a professor of veterinary infectious diseases at the Institute of Infection and Global Health at the University of Liverpool and the International Livestock Research Institute (ILRI), wrote a blog post, “Zoonoses in Africa” on the websitemicrobiologysociety.org, in which he said that urbanisation is presenting opportunities for pathogens to find new hosts to survive.

The post, published on November 11, 2015 read: “The intensification of farming, for example, leads to closer relationships between individuals and animals, generating opportunities for more rapid mutations as organisms move from host to host, while also providing a structured way for those pathogens to enter highly ordered food chains that branch out and reach very large numbers of people”.

Other studies paint an increasingly disturbing pattern of diseases either emerging, or the incidence of existing ones increasing.

A study in Dagoretti, Nairobi, by the International Livestock Research Institute (ILRI), found that women were more exposed to cryptosporidiosis, a diarrhoeal disease transmitted from cattle to humans, because of their involvement in milking, feeding and watering the animals.

And a study by the Kenya Medical and Research Foundation (KEMRI) Kisumu and the US’ CDC linked a strain of tuberculosis to an area in Western Kenya where homes had a higher cattle:human ratio.

In wildlife settings, the situation is more complex. A 2014 study found cases of suspected rabies in Laikipia County where humans had encroached on animal habitat.

When landscapes and bio diversities are altered by activities relating to construction such as roads and farms, diseases are “created”: as trees are felled, the species that protect humans from the ones that act as disease-reservoirs are destroyed.

The harmful pathogens are usually multi-host, meaning they can live in many different animals, which gives them a competitive edge to survive as the protective trees are wiped out by human activity.

In 2012, ILRI reported that 2 million people are killed by zoonoses every year, thanks to the disruption of the ecosystem.

Malaria is a good example: as people in tropical countries like Kenya encroached on the habitat, the incidence of the disease quadrupled.

ECOLOGICAL BALANCE

When DN2 asked nine developers from Nakuru, Nairobi and Kisumu whether they consider the ecological balance of a location important when they are building, six responded with the question, “What is that?” After it was explained to them, all except one said they were “satisfied with the National Environmental Management Authority (NEMA) clearance”.

It is notable that NEMA officials and environmental inspectors have said at scientific forua that many of the constructions approved by the counties do not heed their counsel.

Only 1 per cent solution to wildlife viruses are known, according to WHO, and the ecology of diseases and wildlife immunology is in its infancy in Kenya.

Meanwhile, Kenya’s Zoonotic Disease Unit, has been lauded at various fora for its holistic approach, with its national rabies control strategy highly regarded.

It has conducted a large-scale study on the epidemiology of brucellosis, responded to many zoonotic disease outbreaks, and developed preparedness strategies for epidemic zoonoses such as Rift Valley fever.

But for now, one can only hope that ecological safety will be factored in amid the real estate industry boom.

SOURCE

This article originally appeared in the Kenya Daily Nation website on 9th March, 2016 authored by Verah Okeyo, available athttp://www.nation.co.ke/lifestyle/DN2/Take-care-how-you-interact-with-animals/-/957860/3108294/-/15fadaoz/-/index.html

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